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Serum Erythropoietin, Insulin-Like Growth Factor 1 and Vascular Endothelial Growt Factor in Ethiopathogenesis of Retinopathy of Prematurity
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Original Article
VOLUME: 42 ISSUE: 6
P: 423-428
December 2012

Serum Erythropoietin, Insulin-Like Growth Factor 1 and Vascular Endothelial Growt Factor in Ethiopathogenesis of Retinopathy of Prematurity

Turk J Ophthalmol 2012;42(6):423-428
DOI: 10.4274/tjo.42.63496
Özlem Yenice 1
Ahmed Ashour 1
Eren Çerman 1
Rıdvan Fırat 2
Goncagül Haklar 2
Önder Şirikçi 2
İpek Akman 3
Haluk Kazokoğlu 1
1. Marmara Üniversitesi Tip Fakültesi, Göz Hastaliklari Anabilim Dali, Istanbul, Türkiye
2. Marmara Üniversitesi Tip Fakültesi, Biyokimya Anabilim Dali, Istanbul, Türkiye
3. Marmara Üniversitesi Tip Fakültesi, Pediyatri Anabilim Dali, Istanbul, Türkiye
No information available.
No information available
Received Date: 07.03.2012
Accepted Date: 13.08.2012
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ABSTRACT

Purpose:

The aim of this study was to determine the serum levels of erythropoietin (EPO), vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) that possibly play an important role in the pathogenesis of retinopathy of prematurity (ROP) and to investigate their relationship with each other.

Material and Method:

In this study, 93 infants with gestational age of less than 32 weeks or had a birth weight of less than 2000 g were investigated prospectively. To determine levels of EPO, VEGF and IGF-1, samples were collected from cord blood and were reserved at -80°C. Serum levels of cytokines in babies with and without ROP (ROP+ and ROP-) were determined and their relationship with each other was investigated.

Results:

ROP was found in 57 (61.3%) babies. There was a significant difference between ROP- and ROP+ groups for birth weight (1678.06±326.03 g; 1383.95±343.23 g; p=0,001) and birth week (29.65±2.34 weeks; 32.22±1.49 weeks; p=0,001) correspondingly. Besides, IGF-1 levels correlated significantly with birth weight (r=0.509; p=0.001) and birth week (r=0.586, p=0.001). Median serum levels in ROP(-) group were 19.45 ng/ml (0-40 ng/ml) for IGF-1, 1159.5 pg/ml (396.59-2389.25 pg/ml) for VEGF, and 6.14 mU/ml (2.6-35.4 mU/ml) for EPO. The median serum levels in ROP+ group were 0 ng/ml (0-30.6 ng/ml) for IGF-1, 864.98 pg/ml (182.57-2133.05 pg/ml) for VEGF, and 6.07 mU/ml (2.4-90.2 mU/ml) for EPO. Levels of IGF-1 (p=0.008) and VEGF (p=0.011) were significantly lower in the ROP(+) group. Serum VEGF correlated with EPO levels (r=0.275; p=0.019).

Discussion:

Serum IGF-1 and VEGF levels at birth may be measured to assess the risk for developing ROP. (Turk J Ophthalmol 2012; 42: 423-8)