ABSTRACT

Objectives:

The aim of this study was to evaluate subclinical multiple sclerosis (MS) patients with normal visual acuity using pattern visual evoked potentials (PVEP) test and central 30-2 threshold visual field (VF) test.

Materials and Methods:

A total of 60 patients, 30 of which had a definitive MS diagnosis and 30 who were healthy volunteers, were included in the study. The participants were divided into the following three groups: Group 1 - optic neuritis (+) MS patients, Group 2 - optic neuritis (-) MS patients, and Group 3 - control group. Using white on white perimetry, SITA FAST central 30-2 threshold VF tests and 1˚-0.3˚ PVEP measurements were performed. MD, PSD, p100 latency (ms), p100 amplitude (µV), and central 0-10˚, 0-20˚, 0-30˚, 10-20˚, 10-30˚, 20-30˚ retina sensitivities (db) were evaluated in all groups.

Results:

There was a significant difference in all parameters between Group 1 and Group 3 (p<0.05). There was a significant difference in p100 latency 1˚- 0.3˚, p100 amplitude 0.3˚, central 0-30˚, 10-30˚, 20-30˚ between Group 2 and Group 3 (p<0.05). There was no significant difference in the parameters except for p100 amplitude 1˚ between Group 1 and Group 2 (p>0.05).

Conclusion:

The evaluation of PVEP and central 30˚ VF can be used to monitor disease prognosis in subclinical MS patients.