ABSTRACT
Purpose:
To evaluate the fixation pattern and its relation with preferred retinal locus in eyes with Stargardt disease.
Methods:
MP-1 microperimetry analysis of fixation patterns in 26 eyes of 13 patients with Stargardt disease was done. Patients visual acuity has changed 1/10 to 2/10. The preferred retinal locus was determined and it's relationship with central scotoma was evaluated.
Results:
All eyes had an established preferred retinal locus and all eyes also placed the scotoma above the fixation. Fixation was unstable in 17 eyes (65%) and relative unstable in 9 eyes
Conclusion:
Our results showed that microperimetry is an important method for the evaluation of preferential retinal locus and its relationship with fixation in patients with Stargardt disease.
References
1Lois N, Holder GE, Bunce C, Fitzke FW, Bird AC. Phenotypic subtypes of Stargardt macular dystrophy-fundus flavimaculatus. Arch Ophthalmol 2001;119:359-369.
2Souied EH, Ducroq D, Roset JM, et al. A novel ABCR nonsense mutation responsible for late-onset fundus flavimaculatus. Invest Ophthalmol Vis Sci 1999;40:2740-2744.
3Yen MY, Wei YH, Lui JH. Stargardt type maculopathy in a patient with 11778 Leber's optic neuropathy. J Neuro-Ophthalmol 1996;16:120-123.
4Wakabayashi K, Yonemura D, Kawasaki K. Electrophysiological analysis of Stargardt's disease fundus maculatus group. Doc Ophthalmol 1985;60:141-147.
5Fletcher DC, Schuchard RA. Preferred retinal loci relationship to macular scotomas in a low vision population. Ophthalmology1997;104:632-638.
6Fishman GA, Buckman G, Van Every T. Fundus flavimaculatus:a clinical classification. Doc Ophthalmol Proc Ser 1977;13:213-220.
7Gelisken O, Delaey JJ. Aclinical review of Stargardt disease and/or fundus flavimaculatus with follow-up. Int Ophthalmol 1985;8:225-235.
8Fujii GY, de Juan E, Sunness JS, Humayun MS, Pieramici DJ, Chang TS. Patient selection for macular translocation surgery using the scanning laser ophthalmoscope. Ophthalmology 2002;109:1737-1744.
9Sunness JS, Bressler NM, Tian Y, Alexander J, Applegate CA. Measuring geographic atrophy in advanced agerelated macular degeneration. Invest Ophthalmol Vis Sci 1999;40:1761-1769.
10Aaberg TM. Stargardt's disease and fundus flavimaculatus: evaluation of morphologic progression and intrafamilial co-existence. Trans Am Ophthalmol Soc 1986;84:453-487.
11Schuchard RA. Preferred retinal loci and macular scotoma characteristics in patients with age-related macular degeneration. Can J Ophthalmol 2005;40:303-312.
12Rotenstreich Y, Fishman GA, Anderson RJ. Visual acuity loss and clinical observations in large series of patients with Stargardt's disease. Ophthalmology 2003;110:1151- 1158.
13Fishman GA, Farber M, Patel BS, et al. Visual acuity loss in patients with Stargardt's macular dystrophy. Ophthalmology
141987;94:809-814.
15Sunness JS, Applegate CA, Haselwood D, Rubin GS. Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt's disease. Ophthalmology 1996;103:1458-1466.
