ABSTRACT

Dengue fever is a flavivirus infection transmitted through infected mosquitoes, and is endemic in Southeast Asia, Central and South America, the Pacific, Africa and the Eastern Mediterranean region. A 41-year-old male patient had visual impairment after travelling to Thailand, which is one of the endemic areas. Cotton wool spots were observed on fundus examination. Fundus fluorescein angiography showed minimal vascular leakage from areas near the cotton wool spots and dot hemorrhages in the macula. Dengue fever should be considered in patients with visual complaints who traveled to endemic areas of dngue fever.

Introduction

Dengue fever is an acute viral infection resulting from the transmission of a species of virus in the genus Flavivirus to humans through female mosquitoes of the species Aedes aegypti and Aedes albopticus.¹ Each year around 50-100 million people are infected with the dengue virus worldwide.² Areas in which it is endemic are South Asia, Central and South America, Africa, and Pacific and Eastern Mediterranean countries.³

In dengue fever, a 2 to 7 day incubation period is followed by the sudden onset of symptoms which may include high fever, malaise, headache, retroorbital pain, rhinitis and coughing, nausea and vomiting, and maculopapulary rash. Laboratory tests may reveal thrombocytopenia, leukopenia and hemoconcentration.⁴ Leakage from capillaries and hemorrhage are the basic pathologies of this disease.⁵

Dengue fever patients may have fundus signs such as retinal hemorrhages, macular edema, soft exudates, optic disc edema, vascular sheathing and retinochoroiditis and anterior uveitis.^4,6

This case report presents the fundus findings of a patient hospitalized for dengue fever while traveling in Thailand.

Discussion

Dengue fever is the most common viral infection transmitted by a mosquito vector in the world.⁷ Flaviviruses are single-stranded, positive-sense RNA viruses with icosahedral nucleocapsids.⁶ The most common clinical presentation is dengue fever.⁶

Ocular symptoms in dengue fever are self-limiting and usually spontaneously resolve without treatment.⁴ Ophthalmic findings include retinal hemorrhage, macular edema, soft exudates, optic disc edema, vascular sheathing, retinochoroiditis and anterior uveitis.^4,6 It is believed that the etiopathogenesis of ocular findings related to dengue fever is a mechanism induced more by the immune system than by direct viral infection.⁸ Direct viral infection causes dysfunction and apoptosis of endothelial cells, dendritic cells and monocytes, resulting in cytokine and antibody production. Though not fully proven, it has been proposed that dengue fever maculopathy arises due to the production of antibodies against the retina, retinal pigment epithelium and choroid.⁸ Although controversial, some studies have stated that steroids can be used in cases of maculopathy because it is immune-based.^1,4,7

OCT, FFA and indocyanine green angiography (ICGA) may be performed in cases of dengue-related maculopathy.⁷ Diffuse retinal thickening and cystoid macular edema can be visualized by OCT.⁹ OCT did not reveal an increase in retinal thickness in our case, which we attribute to the late stage of infection. The lower visual acuity in the left eye was explained by changes in the soft exudate area very close to the fovea.

The most common ocular symptom of dengue fever is blurred vision.¹ Visual symptoms emerge one week after acute viral infection, which has been attributed to antibody production and immune complex deposition.¹ Thrombocytopenia, leukopenia and hemoconcentration may occur in dengue fever.⁴ Depending on the course of the disease, increased platelet count has been associated with improvement of visual symptoms.^4,10

In this case, approximately one month had elapsed between the patient’s hospital stay in Thailand and his presentation to our clinic. During this period, the patient’s visual complaints had decreased with time. There were no important findings during examination other than the soft exudates and punctate hemorrhages at the posterior pole of the fundus, especially in the left eye. This was considered consistent with reports in the literature of ocular findings which spontaneously resolved.

Dengue fever is endemic in South Asian, American, Pacific, African and Eastern Mediterranean countries.³ Seroepidemiologic studies have indicated that dengue virus may be also present in Turkey.⁵ In patients who develop visual complaints after travel to endemic areas and/or suspicious mosquito bites, ocular involvement related to dengue fever should be considered.