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Comparison of the Effects of Latanoprost/Timolol Maleate and Dorzolamide/Timolol Maleate Fixed Combinations on Intraocular Pressure and Diurnal Variation in Patients with Primary Open-angle Glaucoma
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Original Article
VOLUME: 40 ISSUE: 2
P: 76-79
March 2010

Comparison of the Effects of Latanoprost/Timolol Maleate and Dorzolamide/Timolol Maleate Fixed Combinations on Intraocular Pressure and Diurnal Variation in Patients with Primary Open-angle Glaucoma

Turk J Ophthalmol 2010;40(2):76-79
Şahin M. Sevim
Didem Esen
Banu Torun Acar
Bülent İ. Buttanrı
1.
No information available.
No information available
Received Date: 07.12.2009
Accepted Date: 19.01.2010
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ABSTRACT

Discussion:

Three-month therapy with LTFC and DTFC effectively reduces IOP in POAG patients during the daytime. LTFC provides better reduction in the diurnal variation.

Results:

Both treatments significantly reduced the IOP during the daytime at the 3rd month. The diurnal variation was significantly lower in the LTFC group (p<0.01).

Material and Method:

96 eyes of 48 patients followed with the diagnosis of PAOG were included in this prospective study. The patients were randomly divided into two groups: the first group (48 eyes) was treated with LTFC and the second group (48 eyes) was treated with DTFC. At the 3rd month of therapy, the IOP was measured every 2 hours between 8:00 am and 8:00 pm.

Purpose

To compare the intraocular pressure (IOP)-lowering effect and diurnal variation of Latanoprost/Timolol Maleate (LTFC) and Dorzolamide/Timolol Maleate(DTFC) fixed combinations in patients with primary open-angle glaucoma (POAG).