EN | TR
E-ISSN: 2147-2661
A Case Of Orbital Metastatic Neuroblastoma Misdiagnosed As Orbital Trauma
PDF
Cite
Share
Request
Case Report
VOLUME: 38 ISSUE: 2
P: 164-167
March 2008

A Case Of Orbital Metastatic Neuroblastoma Misdiagnosed As Orbital Trauma

Turk J Ophthalmol 2008;38(2):164-167
Meral Yıldız 1
Bülent Yazıcı 2
Metin Demirkaya 3
Betül Sevinir 3
1.
2.
3.
No information available.
No information available
Received Date: 19.11.2007
Accepted Date: 22.02.2008
PDF
Cite
Share
Request

ABSTRACT

Neuroblastoma may manifest with symptoms due to metastasis to the orbit. This condition may be mistaken for orbital trauma. In this report, a 10 months-old patient with metastatic orbital neuroblastoma who was previously diagnosed as orbital trauma has been presented. The presenting sypmtoms were left proptosis and the appearance of racoon eyes. The diagnosis of neuroblastoma was made by typical radiological study, blood and urine findings and bone marrow aspiration biopsy. The ophthalmological findings regressed after multiple chemotherapy with multidrug and disappeared 5 months after the treatment. However, 10 months after the initiation fo the treatment, the patient was lost due to bone and lung metastasis and fulminating sepsis secondary to febrile neutropeni.

Keywords:
Neuroblastoma, orbital metastasis, trauma

References

1
Musarella MA, Chan HS, DeBoer G, Gallie BL. Ocular involvement in neuroblastoma: prognostic implications. Ophthalmology 1984;91:936-40.
2
Belgaumi AF, Kauffman WM, Jenkins JJ et al. Blindness in children with neuroblastoma. Cancer 1997;80:1997-2004.
3
Timmerman R. Raccoon eyes and neuroblastoma. N Engl J Med 349;42:4.
4
Ahmed S, Goel S, Khandwala, at al. Neuroblastoma with orbital metastasis: ophthalmic presentation and role of ophthalmologist. Eye 2006;20:466-70.
5
Rudnick E, Khakoo Y, Antunes NL et al. Opsoclonusmyoclonus-ataxia syndrome in neuroblastoma: clinical outcome and antineuronal antibodies-a report from the Children's Cancer Group Study. M ed Pediatr Oncol 2001; 36:612-22.
6
Castleberry RP. Biology and treatment of neuroblastoma. Pediatr Clin North Am 1997; 44:919-37.
7
Monsaingeon M, Perel Y, Simonnet G, Corcuff JB. Comparative values of catecholamines and metabolites for the diagnosis of neuroblastoma. Eur J Pediatr 2003; 162:397-402.
8
DuBois SG, Kalika Y, Lukens JN et al. Metastatic sites in stage IV and IVs neuroblastoma correlate with age, tumor biology, and survival. J Pediatr Hematol Oncol 1999;21:181-89.
9
Grosfeld JL. Risk-based management: current concepts of treating malignant solid tumors of childhood. J Am Coll Surg 1999;189:407-25.