Purpose:

To compare the clinical results of prophylactic intracameral cefuroxime (10 mg/ml) and subconjunctival gentamicin (20mg/ml) after cataract surgery.

Materials and Methods:

864 eyes of 685 patients with senile cataract were included in this prospective study which was done between June 2006 and June 2007. Patients were categorized into 2 groups. In the first group, prophylactic intracameral cefuroxime ( Zinnat® Floc. Glaxo-Smith) was applied to 432 eyes just after the surgery. In the second group (432 eyes), subcojunctival gentamicin was injected just after the surgery.Postoperative best corrected visual acuity (BCVA), and complications were evaluated.

Results:

Mean follow up 6,2±1,78 months. Mean age of the patients was 69,5±9.3 years. Postoperative best corrected visual acuity was 0,7±0,25. In the first postoperative day, fibrin reaction was observed in 5 eyes (% 1,15) of the first group and 14 eyes of the second group (% 3.24). Anterior chamber haze was seen in 12% of the first group and 25% of the second group. The differences in these parameters were statistically significant (p<0.05). No cases of endophthalmitis were observed during the follow up period.

Conclusion:

Intracameral cefuroxime 10 mg/ml appeared to be more effective than subconjunctival gentamicin (20mg/ml) for the prophylaxis of endophthalmitis after cataract surgery.

Keywords: Intracameral Cefuroxime, Gentamicin, Endophthalmitis, Cataract