Original Article

Correlation of Serum Acute Phase Reactants and Lipid Levels with Retinal Vascular Complications of Type 2 Diabetes - Original Article

  • Ramazan Yağcı
  • Mesut Erdurmuş
  • Muhammet Necati Demir
  • Yusuf Oflu
  • Nurten Ünlü
  • Mustafa Durmuş
  • Firdevs Örnek

Received Date: 19.04.2007 Accepted Date: 21.09.2007 Turk J Ophthalmol 2008;38(3):230-235


To investigate the serum acute phase reactants like fibrinogen and C-reactive protein (CRP) and serum lipid profile in association with the development of retinal vascular complications in patients with type 2 diabetes.


Patients with type 2 diabetes without retinopathy (NoRP) (n=35), with nonproli-ferative retinopathy (NPDR) (n=35) and proliferative diabetic retinopathy (PDR) (n=35) were included in the study. Age and sex matched healthy persons (n=35) accepted as control group. Serum fibrinogen, CRP, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, and triglyceride levels were determined in all participants. Data obtaining from gro-ups were compared each other.


There was no significant difference of age and sex among groups (p>0.05). Plas-ma fibrinogen levels in study groups were found significantly higher than the control group (p= 0.001). Plasma CRP levels in PDR group were significantly lower than the other groups (p= 0.04). NPDR, NoRP and control groups were not significantly different by means of CRP levels (p=0.84). HDL and LDL concentrations were not found different among groups (p=0.16; p= 0.09). Plasma total cholesterol and triglyceride levels were higher in study groups than the control group (p=0.02; p<0.001). There were no difference in study groups in terms of total cholesterol and triglyceride levels (p=0.58; p=0.70).


Elevated levels of serum fibrinogen and changed lipid profile were determined in patients with type 2 diabetes.

Keywords: Type 2 diabetes, acute phase reactants, lipid profile

Full Text (Turkish)