Pur­po­se:

To compare the optical coherence tomography (OCT) measurements using posterior pole analysis (PPA) and macular thickness measurement mode in pediatric cases with unilateral anisometropic amblyopia.

Ma­te­ri­al and Met­hod:

This study included 74 eyes of 37 patients aging between 6-17 years with unilateral anisometropic amblyopia. PPA and macular thickness measurement mode OCT scans were performed, and measurements of amblyopic and fellow eyes were evaluated. All OCT scans were performed by a single experienced doctor without pupil dilation within one session. Measurement sequence was randomly assigned for PPA and macular thickness measurement mode for amblyopic and fellow eyes. Retinal thickness measurements by using PPA and macular thickness measurement mode were compared using the paired samples t-test. Statistical analyses of retinal thickness differences between the amblyopic and fellow eyes were determined using the independent samples t-test.

Re­sults:

PPA and macular thickness measurement mode results of the amblyopic eyes did not reveal any statistically significant difference for all studied segments (p-values for all segments were over 0.10). PPA and macular thickness measurement mode results of the felloww eyes did not reveal any statistically significant difference for all studied segments (p-values for all segments were over 0.16), except for the temporal segment (p=0.04). There was no statistically significant difference between macular thickness of the amblyopic and fellow eye for both measurement modes.

Dis­cus­si­on:

Macular thickness measurements using different scanning modes of OCT revealed similar retinal thickness in amblyopic and fellow eyes of patients with unilateral anisometropic amblyopia, but temporal macular segment measurements should be evaluated cautiously.

Keywords: Amblyopia, macula, optical coherence tomography, posterior pole analysis